Jacek Zielonka Selected Research

triphenylphosphonium

12/2017	Modified Metformin as a More Potent Anticancer Drug: Mitochondrial Inhibition, Redox Signaling, Antiproliferative Effects and Future EPR Studies.
11/2014	A novel mitochondrially-targeted apocynin derivative prevents hyposmia and loss of motor function in the leucine-rich repeat kinase 2 (LRRK2(R1441G)) transgenic mouse model of Parkinson's disease.
1/2013	Mito-tempol and dexrazoxane exhibit cardioprotective and chemotherapeutic effects through specific protein oxidation and autophagy in a syngeneic breast tumor preclinical model.
10/2011	Mitochondria-targeted nitroxides exacerbate fluvastatin-mediated cytostatic and cytotoxic effects in breast cancer cells.
2/2009	Doxorubicin inactivates myocardial cytochrome c oxidase in rats: cardioprotection by Mito-Q.

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Jacek Zielonka Research Topics

Disease

26	Neoplasms (Cancer) 01/2020 - 04/2006
6	Breast Neoplasms (Breast Cancer) 11/2019 - 11/2010
4	Mitochondrial Diseases (Mitochondrial Disease) 11/2020 - 01/2012
4	Neoplasm Metastasis (Metastasis) 01/2020 - 11/2008
4	Pancreatic Neoplasms (Pancreatic Cancer) 12/2017 - 08/2015
4	Parkinson Disease (Parkinson's Disease) 11/2014 - 09/2012
3	Carcinogenesis 01/2020 - 01/2018
3	Inflammation (Inflammations) 01/2018 - 12/2008
2	Cardiovascular Diseases (Cardiovascular Disease) 01/2021 - 12/2017
2	Hypoxia (Hypoxemia) 01/2020 - 11/2019
2	Cardiotoxicity 05/2019 - 01/2013
2	Lung Neoplasms (Lung Cancer) 01/2019 - 05/2018
2	Cardiomyopathies (Cardiomyopathy) 01/2013 - 02/2009
1	Septic Shock (Toxic Shock Syndrome) 06/2022
1	Reperfusion Injury 01/2022
1	Hypertension (High Blood Pressure) 01/2021
1	Brain Injuries (Brain Injury) 01/2021
1	Radiation Injuries (Radiation Sickness) 01/2021
1	Adenocarcinoma 01/2020
1	Thrombosis (Thrombus) 01/2020
1	Dyslipidemias (Dyslipidemia) 01/2020
1	Melanoma (Melanoma, Malignant) 01/2020
1	Mouth Neoplasms (Oral Cancer) 01/2020
1	Triple Negative Breast Neoplasms 05/2019
1	Neurodegenerative Diseases (Neurodegenerative Disease) 01/2019
1	Brain Neoplasms (Brain Tumor) 05/2018
1	Infections 01/2018
1	Colonic Neoplasms (Colon Cancer) 01/2018
1	Neuroinflammatory Diseases 11/2017
1	Disease Progression 10/2017
1	Anosmia 11/2014
1	Carcinoma (Carcinomatosis) 10/2014

Drug/Important Bio-Agent (IBA)

11	Reactive Oxygen Species (Oxygen Radicals)IBA 01/2020 - 11/2008
9	Superoxides (Superoxide)IBA 01/2021 - 12/2008
6	Hydrogen Peroxide (Hydroperoxide)FDA LinkGeneric 01/2020 - 08/2015
5	Oxidants (Oxidizing Agents)IBA 01/2020 - 09/2012
5	AntioxidantsIBA 01/2018 - 10/2011
5	Pharmaceutical PreparationsIBA 01/2018 - 10/2011
5	triphenylphosphoniumIBA 12/2017 - 02/2009
4	Metformin (Glucophage)FDA LinkGeneric 05/2019 - 01/2016
4	Phosphotransferases (Kinase)IBA 12/2017 - 11/2010
3	Proteins (Proteins, Gene)FDA Link 01/2020 - 01/2013
3	Adenosine Triphosphate (ATP)IBA 01/2020 - 06/2013
3	nitroxylIBA 01/2018 - 10/2011
3	Hypoglycemic Agents (Hypoglycemics)IBA 12/2017 - 01/2016
3	mito-carboxy proxylIBA 08/2015 - 01/2012
2	Nitric Oxide (Nitrogen Monoxide)FDA Link 06/2022 - 04/2006
2	NitrogenIBA 01/2020 - 08/2013
2	PeroxiredoxinsIBA 01/2020 - 01/2019
2	Oxygen (Dioxygen)IBA 01/2020 - 08/2013
2	Superoxide DismutaseIBA 11/2019 - 01/2012
2	Dexrazoxane (Zinecard)FDA LinkGeneric 05/2019 - 01/2013
2	Chelating AgentsIBA 05/2019 - 03/2011
2	IronIBA 05/2019 - 03/2011
2	EnzymesIBA 01/2019 - 04/2006
2	acetovanillone (apocynin)IBA 11/2017 - 11/2014
2	diapocyninIBA 11/2014 - 08/2013
2	Leucine (L-Leucine)FDA Link 11/2014 - 08/2013
2	Free RadicalsIBA 10/2014 - 08/2014
2	Doxorubicin (Adriamycin)FDA LinkGeneric 01/2013 - 02/2009
2	Antineoplastic Agents (Antineoplastics)IBA 01/2012 - 04/2006
2	mitoquinoneIBA 11/2010 - 02/2009
2	UbiquinoneIBA 11/2010 - 02/2009
2	Nitric Oxide Synthase (NO Synthase)IBA 02/2009 - 04/2006
1	Fluorescein (Funduscein)FDA LinkGeneric 01/2022
1	Angiotensin-Converting Enzyme Inhibitors (ACE Inhibitors)IBA 01/2021
1	hydropropidineIBA 01/2021
1	Cytochrome P-450 CYP2E1 (CYP2E1)IBA 11/2020
1	Aconitate Hydratase (Aconitase)IBA 01/2020
1	src-Family KinasesIBA 01/2020
1	4-Nitroquinoline-1-oxide (4 Nitroquinoline 1 oxide)IBA 01/2020
1	oxidized low density lipoproteinIBA 01/2020
1	Cysteine (L-Cysteine)FDA Link 01/2020
1	Scavenger Receptors (Scavenger Receptor)IBA 01/2020
1	LipidsIBA 01/2020
1	LDL Lipoproteins (beta Lipoproteins)IBA 01/2020
1	LuciferasesIBA 01/2020
1	magnololIBA 01/2020
1	LuciferinsIBA 01/2020
1	Lysine (L-Lysine)FDA Link 11/2019
1	Transcription Factors (Transcription Factor)IBA 11/2019
1	Deferasirox FDA Link 05/2019
1	Protein Isoforms (Isoforms)IBA 01/2019
1	NADP (NADPH)IBA 01/2019
1	Oxidoreductases (Dehydrogenase)IBA 01/2019
1	70-kDa Ribosomal Protein S6 Kinases (Ribosomal Protein S6 Kinases, 70 kDa)IBA 01/2019
1	lonidamineIBA 01/2019
1	honokiolIBA 05/2018
1	monooxyethylene trimethylolpropane tristearate (MTTS)IBA 01/2018
1	Therapeutic UsesIBA 01/2018
1	IntegrinsIBA 01/2018
1	NADPH Oxidases (NAD(P)H oxidase)IBA 12/2017
1	Radiation-Sensitizing AgentsIBA 01/2016
1	Fluorescent Dyes (Fluorescent Probes)IBA 10/2014
1	Reactive Nitrogen SpeciesIBA 10/2014
1	LipopolysaccharidesIBA 08/2014

Therapy/Procedure

6	Therapeutics 05/2019 - 10/2011
1	Radiotherapy 01/2021
1	Chemoprevention 01/2020
1	Drug Therapy (Chemotherapy) 05/2019